Personalized Physiology-Guided Resuscitation in Highly Monitored Patients With Cardiac Arrest—the PERSEUS Resuscitation Protocol
Highlights
- Immediately after the abrupt loss of effective blood flow, the hypotension-induced baroreflex withdrawal with the net increase in the vascular resistance maintains an impaired antegrade and pulmonary blood flow (View Highlight)
- When arterial and systemic venous pressures reach equilibrium, the mean systemic filling pressure (Pmsf) is approximately 6–12 mmHg (View Highlight)
- At the same time, cerebral perfusion decreases while the damage of fatty acids of the neuronal cell membrane by reactive oxygen species leads to a progressive increase in membrane permeability and severe derangements of intracellular electrolytes, resulting in cell swelling and brain edema formation [10]. This, together with venous congestion, increases intracranial pressure (ICP) and damages the neuropil and synaptic structures and/or contacts. (View Highlight)
- even during optimal CPR, the cardiac output is between 25 and 40% of pre-arrest values while the coronary arteries receive 5–15% of this amount (View Highlight)